ORetine: Eye & Vision food supplement

ORetine |
Regular price29,00€
/
60 Capsules to protect your eyes from age-related damage, reduce fatigue and improve your eye comfort

👨‍⚕️ Produit unique issu de 15 années de recherche scientifique avec des ophtalmologues et des pharmaciens

👩‍🔬 La formule la plus complète et efficace avec 17 actifs longue durée et hautement concentrés

🇫🇷 Une fabrication éthique, en Occitanie, sans additifs ni excipients controversés

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  • Commander par télephone 04 12 10 28 82

What are the benefits of ORetine vision dietary supplement?

Currently, 40% of French people believe that each year they have more vision problems than the previous year. Prolonged exposure to screens, lifestyle, bad sunglasses, nutritional deficiencies, the reasons are long to explain these discomforts.

ORetine is a nutraceutical food supplement that has been thought out and designed with rigor and care with the aim of preserving vision , preventing its alterations, and maintaining normal vision.

We are often asked this question: What is the best dietary supplement for the eyes?

No supplement completely replaces a varied and balanced diet, nor does it replace medical advice and treatment, but we have thought of ORetine to naturally include the elements necessary to improve visual comfort and maintain normal vision .

ORetine has been designed to provide you with the best vitamins and nutrients for the eyes, but also for the whole organism.

ORetine is a particularly interesting food supplement in the prevention of age-related pathologies but also during different life situations:

  • Signs of age-related vision loss

  • Decreased visual acuity at night

  • Dry eye

  • Chronic eyestrain

  • Screen work

  • Repeated exposure to blue light

  • Repeated UV exposure

  • Prevention of eye pathologies linked to aging ( AMD , cataracts , etc.)

  • Unbalanced diet

Reminder: What is AMD ← Click to view reminder

Age-related pathologies are likely to significantly alter visual function.

Among these AMD or Age-Related Macular Degeneration is the leading cause of blindness (lack of perception of light → loss of sight) before the age of 50 and affects the macula . The macula is the central area of ​​the retina where the image focused by the lens is formed. This area is very rich in carotenoid pigments (such as lutein).

ORetine has been designed with the main objective of maintaining and maintaining visual function, but it is also a super multivitamin , it contains micronutrients , vitamins , antioxidants but also active ingredients such as CDP-choline or coenzymeQ10 which have proven themselves in particular in improving or maintaining cognitive functions .

What are the ingredients of the ORetine dietary supplement?

ORetine is a complex of several types of ingredients that can be grouped into 4 main categories:

Illustration nutrients

Glutathione , CoQ10 , vitamins C and E , Selenium and Zinc

A set of nutrients that have, among other things, antioxidant capacity to fight against oxidative stress.

illustration plant pigments

Plant pigments

Extracts of marigold flower (lutein) , Haematococcus pluvialis algae (astaxanthin) , grape seed (OPC) and blueberry provide pigments essential for maintaining vision and maintaining carotenoid levels in the body. the retina.

 

Help regulate blood circulation, but also are beneficial for intellectual functions.

illustration vitamins

Vitamins B1 , B2 , B3 , B5 , B6 , and D

Vitamins essential for the proper use of other nutrients and the optimal functioning of the body and the various physiological functions (see health claims).

What makes ORetine a unique nutraceutical dietary supplement for vision?

The initial formula of ORetine was designed 15 years ago by Dr. Petra Kunze and Dr. Jean-Paul Amar, renowned ophthalmologists and pioneers in the use of micronutrients to treat visual comfort issues.

Since then, we have evolved ORetine as new scientific studies appear on the effectiveness of certain natural ingredients, and as technological progress allows us to include more ingredients.

Recently, we benefited from the wise advice of Dr. Chantal Marion, PhD. lecturer at the Faculty of Pharmacy of Montpellier, and Dr. Arnaud Bernard. PhD. Chief Scientific Officer at Phytocea, specialist in nutrition physiology to oversee the latest modifications to the ORetine formula.

The uniqueness of ORetine comes from its extremely complete formula and the diversity of its benefits around vision . In addition to providing the nutrients essential to visual functioning, it also includes micronutrients acting on microcirculation, the protection of retinal cells against oxidative stress, the improvement of the transmission of information to the brain,...

This unique complex of 17 active ingredients is registered and approved by the DGCCRF, and represents a real evolution in the field of visual well-being.

Detailed composition of ORetine and manufacture

ORetine is a food supplement composed of:

Oleoresin rich in astaxanthin extracted from the seaweed Haematococcus pluvialis ( Haematococcus pluvialis ) titrated in astaxanthin**, CDP choline (citicoline), Grape seed extract ( Vitis vinifera ) titrated in OPC (procyanidolic oligomers) , Rose flower extract India (Tagetes erecta) titrated in lutein, L-glutathione reduced**, Ginkgo leaf extract ( Ginkgo biloba ) titrated in glycosides , Purslane aerial part powder (Portulaca oleracea) , Coenzyme Q10**, Zinc glycinate, S elenomethionine, Blueberry fruit extract ( Vaccinium myrtillus ) , Thiamine hydrochloride (vitamin B1), Riboflavin (vitamin B2), Nicotinamide (niacin - Vitamin B3), Calcium D-pantothenate (pantothenic acid - Vitamin B5), Hydrochloride of Pyridoxine (Vitamin B6), Calcium L-ascorbate (Vitamin C), Cholecalciferol (Vitamin D), D-alpha-tocopheryl acetate (Vitamin E), Rice extract, Pullulan vegetable capsule

*Ingredients from Organic Farming

**Ingredients from the fermentation process

Nutritional information for a daily dose (2 capsules)

Ingredients in mg for 2 capsules in % of AR*
Grape seed extract 40mg -
- of which OPC 28mg -
Indian rose flower extract 50mg -
- of which lutein 10mg -
Bilberry extract (berry) 40mg -
Gingko Biloba leaf extract 40mg -
Purslane aerial part powder 40mg -
Astaxanthin-rich oleoresin extracted from Haematococcus pluvialis seaweed
80mg -
- of which astaxanthin 4mg -
CDP Choline 50mg -
Reduced L-Glutathione 60mg -
Coenzyme Q10 20mg -
Zinc 11mg 92%
Selenium 55mcg 79%
Vitamin C 20mg 18%
Vitamin E 20mg 160%
Vitamin B1 1.3mg 100%
Vitamin B2 0.84mg 60%
Vitamin B3 9.6mg 60%
Vitamin B5 7.2mg 120%
Vitamin B6 1.7mg 100%
Vitamin D3 5 mcg 33%
* RI = Reference intakes for an adult male


The particularity of ORetine comes from the diversity and the quantity of ingredients that we will seek from trusted producers. The grape seeds, for example, come from a winery in Costières de Nîmes, the lutein comes from Microphyt, a micro-algae grower near Montpellier, ...

Once the ingredients are combined, ORetine is manufactured according to our guidelines by our manufacturing partner Phytocosma in the Gers, specialists in the plant and in the dry form of food supplements.

Dosage and taking instructions

The dosage of ORetine is 2 capsules per day to be taken with a large glass of water.

The consumption of ORetine can raise the levels of retinal pigments for several months.

We therefore recommend an initial cure of 2 months of ORetine, renewable regularly. A personalized duration of the cure can be evaluated by a doctor, do not hesitate to consult your doctor or your ophthalmologist.

The preservation of the eyes also goes through a healthy lifestyle, and some applicable tips to easily protect your eyes:

  • Always wear sunglasses in bright light

  • Add nuts and shelled fruits, egg, spinach, broccoli, oily fish to your diet to provide essential nutrients for vision.

  • Ensure a sufficient intake of Omega 3 (fatty fish) in the diet, i.e. twice 150g per week, or balance with food supplements based on Omega 3 (see our Omega complex -3 vegetarian)

    Contraindications, precautions for use and adverse effects

    • Do not use in case of known intolerance to any of the components.

    • Do not exceed the recommended daily dose.

    • Food supplements should be used as part of a healthy lifestyle and a varied and balanced diet.

    • Use in pregnant or breastfeeding women is not recommended.

    • Consult your doctor in case of simultaneous intake of anticoagulants or treatment of hypertension.

    • Use in people on antidepressant treatment is not recommended.

    • Keep out of reach of children.

    • Consumption reserved for adults

    • Prolonged use without medical advice is not recommended.

    • It is recommended to consult a doctor in the event of a specific pathology declared.

    Specific precautions linked to certain ingredients:

    Ginkgo biloba
    • People taking anticoagulant (blood thinner) medications should refrain from taking ginkgo products
    • People taking medication for high blood pressure should seek the advice of a physician before use
    • It is recommended to stop taking ginkgo three to four days before surgery
    • Headaches, digestive disorders ( diarrhea , bloating , gas, etc.), as well as allergic manifestations may occur after taking Ginkgo

    What are the health claims of the ORetine dietary supplement?

    Vitamin B1 in ORetine can claim to contribute:

    • normal energy metabolism
    • to the normal functioning of the heart
    • normal functioning of the nervous system and normal intellectual abilities

    ORetine by its vitamin B2 contribution can claim to contribute:

    • normal energy metabolism
    • normal functioning of the nervous system
    • maintenance of normal skin and mucous membranes
    • with normal vision
    • maintenance of normal red blood cells
    • normal iron metabolism
    • to the reduction of fatigue
    • protect cells against free radicals

    Vitamin B3 in ORetine contributes:

    • normal energy metabolism
    • normal functioning of the nervous system
    • maintenance of normal skin and mucous membranes
    • to normal physiological functions
    • to the reduction of fatigue

    Vitamin B5 in ORetine contributes:

    • normal energy metabolism
    • with normal intellectual capacity
    • to the synthesis of steroid hormones
    • to the synthesis of vitamin D
    • to the synthesis of certain neurotransmitters
    • to the reduction of fatigue

    ORetine by its vitamin D contribution can claim to contribute:

    • intestinal absorption and utilization of calcium and phosphorus
    • maintaining normal blood calcium levels
    • to the normal growth of children's bones
    • to maintain the normal state of the bones
    • maintaining the normal state of the muscles
    • to maintain the normal state of the teeth
    • to maintain the normal state of the immune system
    • to cell division

    ORetine by its vitamin E contribution can claim to contribute:

    • the protection of cells against free radicals (antioxidant effect)

    ORetine by its zinc contribution can claim to contribute:

    • to normal DNA synthesis
    • normal acid-base metabolism
    • normal food metabolism
    • normal carbohydrate (sugar) metabolism
    • normal fatty acid metabolism
    • normal vitamin A metabolism
    • to normal intellectual functions
    • to normal fertility and reproduction
    • to protein synthesis
    • maintaining bones
    • maintenance of hair, nails and skin
    • maintaining normal testosterone levels in the blood
    • with normal vision
    • the normal functioning of the immune system
    • to cell division
    • protect cells against free radicals

    What the science says

    The AREDS and AREDS 2 studies that were used to develop our formula ← Click to see the references

    (1) Age-Related Eye Disease Studies (AREDS/AREDS2)

    (2) AREDS2 Research Group, Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012 Nov;119(11):2282-9. doi: 10.1016/j.ophtha.2012.05.027.

    (3) Sangiovanni JP, Agron E, Meleth AD, Reed GF, Sperduto RD, Clemons TE, Chew EY; Age-Related Eye Disease Study Research Group. {omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study. Am J Clin Nutr. 2009 Dec;90(6):1601-7. doi: 10.3945/ajcn.2009.27594.

    (4) Kowluru RA, Kanwar M, Chan PS, Zhang JP. Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Arch Ophthalmol. 2008 Sep;126(9):1266-72. doi: 10.1001/archopht.126.9.1266.

    Proanthocyanidins extracted from grape seeds protect the lens from oxidative stress ← Click to see references

    (5) Jia Z, Song Z, Zhao Y, Wang X, Liu P. Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-кB and MAPK protein expression. MolVis. 2011 Jan 20;17:210-7.

    (6) Sun Y, Xiu C, Liu W, Tao Y, Wang J, Qu YI. Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway. Exp Ther Med. 2016 Apr;11(4):1253-1258. doi: 10.3892/etm.2016.3033.

    Coenzyme Q10, which decreases with age, exerts a protective effect on the retina ← Click to see references

    (7) Qu J, Kaufman Y, Washington I. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1814-8. doi: 10.1167/iovs.08-2656.

    (8) Sangsefidi ZS, Yaghoubi F, Hajiahmadi S, Hosseinzadeh M. The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Food Sci Nutr. 2020 Mar 19;8(4):1766-1776. doi: 10.1002/fsn3.1492.

    (9) Manzar H, Abdulhussein D, Yap TE, Cordeiro MF. Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain. Int J Mol Sci. 2020 Dec 6;21(23):9299. doi: 10.3390/ijms21239299.

    Bilberry (thanks to these polyphenols and antocyanins) has night vision protection and improvement effects ← Click to see references

    (10) Chu WK, Cheung SCM, Lau RAW, Benzie IFF. Bilberry (Vaccinium myrtillus L.). In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.

    (11) Kalt W, McDonald JE, Fillmore SA, Tremblay F. Blueberry effects on dark vision and recovery after photobleaching: placebo-controlled crossover studies. J Agric Food Chem. 2014 Nov 19;62(46):11180-9. doi: 10.1021/jf503689c.

    (12) Liu Y, Zhang D, Hu J, Liu G, Chen J, Sun L, Jiang Z, Zhang X, Chen Q, Ji B. Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols. J Agric Food Chem. 2015 Oct 28;63(42):9295-305. doi: 10.1021/acs.jafc.5b04341.

    CDP-Choline (citicoline) exerts neuroprotective effects ← Click to view references

    (13) Parisi V, Coppola G, Ziccardi L, Gallinaro G, Falsini B. Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy. Eur J Neurol. 2008 May;15(5):465-74. doi: 10.1111/j.1468-1331.2008.02099.x.

    (14) Arenth PM, Russell KC, Ricker JH, Zafonte RD. CDP-choline as a biological supplement during neurorecovery: a focused review. PM R. 2011 Jun;3(6 Suppl 1):S123-31. doi: 10.1016/j.pmrj.2011.03.012.

    (15) Park CH, Kim YS, Noh HS, Cheon EW, Yang YA, Yoo JM, Choi WS, Cho GJ. Neuroprotective effect of citicoline against KA-induced neurotoxicity in the rat retina. Exp Eye Res. 2005 Sep;81(3):350-8. doi: 10.1016/j.exer.2005.02.007.

    Astaxanthin, its antioxidant and anti-inflammatory effects on the retina and the body ← Click to see references

    (16) Otsuka T, Shimazawa M, Nakanishi T, Ohno Y, Inoue Y, Tsuruma K, Ishibashi T, Hara H. Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage. J Pharmacol Sci. 2013;123(3):209-18. doi: 10.1254/jphs.13066fp.

    (17) Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011 Dec;16(4):355-64.

    (18) Lin CW, Yang CM, Yang CH. Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model. Mar Drugs. 2020 Jul 25;18(8):387. doi: 10.3390/md18080387.

    Lutein (a carotenoid) is an essential component of the eye and helps protect against AMD ← Click to view references

    (19) Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013 May 15;309(19):2005-15. doi: 10.1001/jama.2013.4997.

    (20) Murray IJ, Makridaki M, van der Veen RL, Carden D, Parry NR, Berendschot TT. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Invest Ophthalmol Vis Sci. 2013 Mar 11;54(3):1781-8. doi: 10.1167/iovs.12-10715.

    (21) Li LH, Lee JC, Leung HH, Lam WC, Fu Z, Lo ACY. Lutein Supplementation for Eye Diseases. Nutrients. 2020 Jun 9;12(6):1721. doi: 10.3390/nu12061721.

    Purslane is an anti-inflammatory and anti-oxidant ← Click to see references

    (22) Rahimi VB, Ajam F, Rakhshandeh H, Askari VR. A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti-Oxidant, Immuno-Modulatory and Antitumor Activities. J Pharmacopuncture. 2019 Mar;22(1):7-15. doi: 10.3831/KPI.2019.22.001.

    INSERM press release: What should you eat to prevent the onset or slow the progression of AMD? ← Click to see references

    (23) Consuming a diet rich in carotenoids lowers the risk of developing AMD

    The information in this sheet takes into account the framework of authorized health claims in accordance with European legislation on food supplements (EC No. 1924/2006).

    BENEFITS

    What are the benefits of ORetine vision dietary supplement?

    Currently, 40% of French people believe that each year they have more vision problems than the previous year. Prolonged exposure to screens, lifestyle, bad sunglasses, nutritional deficiencies, the reasons are long to explain these discomforts.

    ORetine is a nutraceutical food supplement that has been thought out and designed with rigor and care with the aim of preserving vision , preventing its alterations, and maintaining normal vision.

    We are often asked this question: What is the best dietary supplement for the eyes?

    No supplement completely replaces a varied and balanced diet, nor does it replace medical advice and treatment, but we have thought of ORetine to naturally include the elements necessary to improve visual comfort and maintain normal vision .

    ORetine has been designed to provide you with the best vitamins and nutrients for the eyes, but also for the whole organism.

    ORetine is a particularly interesting food supplement in the prevention of age-related pathologies but also during different life situations:

    • Signs of age-related vision loss

    • Decreased visual acuity at night

    • Dry eye

    • Chronic eyestrain

    • Screen work

    • Repeated exposure to blue light

    • Repeated UV exposure

    • Prevention of eye pathologies linked to aging ( AMD , cataracts , etc.)

    • Unbalanced diet

    Reminder: What is AMD ← Click to view reminder

    Age-related pathologies are likely to significantly alter visual function.

    Among these AMD or Age-Related Macular Degeneration is the leading cause of blindness (lack of perception of light → loss of sight) before the age of 50 and affects the macula . The macula is the central area of ​​the retina where the image focused by the lens is formed. This area is very rich in carotenoid pigments (such as lutein).

    ORetine has been designed with the main objective of maintaining and maintaining visual function, but it is also a super multivitamin , it contains micronutrients , vitamins , antioxidants but also active ingredients such as CDP-choline or coenzymeQ10 which have proven themselves in particular in improving or maintaining cognitive functions .

    INGREDIENTS

    What are the ingredients of the ORetine dietary supplement?

    ORetine is a complex of several types of ingredients that can be grouped into 4 main categories:

    Illustration nutrients

    Glutathione , CoQ10 , vitamins C and E , Selenium and Zinc

    A set of nutrients that have, among other things, antioxidant capacity to fight against oxidative stress.

    illustration plant pigments

    Plant pigments

    Extracts of marigold flower (lutein) , Haematococcus pluvialis algae (astaxanthin) , grape seed (OPC) and blueberry provide pigments essential for maintaining vision and maintaining carotenoid levels in the body. the retina.

     

    Help regulate blood circulation, but also are beneficial for intellectual functions.

    illustration vitamins

    Vitamins B1 , B2 , B3 , B5 , B6 , and D

    Vitamins essential for the proper use of other nutrients and the optimal functioning of the body and the various physiological functions (see health claims).

    What makes ORetine a unique nutraceutical dietary supplement for vision?

    The initial formula of ORetine was designed 15 years ago by Dr. Petra Kunze and Dr. Jean-Paul Amar, renowned ophthalmologists and pioneers in the use of micronutrients to treat visual comfort issues.

    Since then, we have evolved ORetine as new scientific studies appear on the effectiveness of certain natural ingredients, and as technological progress allows us to include more ingredients.

    Recently, we benefited from the wise advice of Dr. Chantal Marion, PhD. lecturer at the Faculty of Pharmacy of Montpellier, and Dr. Arnaud Bernard. PhD. Chief Scientific Officer at Phytocea, specialist in nutrition physiology to oversee the latest modifications to the ORetine formula.

    The uniqueness of ORetine comes from its extremely complete formula and the diversity of its benefits around vision . In addition to providing the nutrients essential to visual functioning, it also includes micronutrients acting on microcirculation, the protection of retinal cells against oxidative stress, the improvement of the transmission of information to the brain,...

    This unique complex of 17 active ingredients is registered and approved by the DGCCRF, and represents a real evolution in the field of visual well-being.

    Detailed composition of ORetine and manufacture

    ORetine is a food supplement composed of:

    Oleoresin rich in astaxanthin extracted from the seaweed Haematococcus pluvialis ( Haematococcus pluvialis ) titrated in astaxanthin**, CDP choline (citicoline), Grape seed extract ( Vitis vinifera ) titrated in OPC (procyanidolic oligomers) , Rose flower extract India (Tagetes erecta) titrated in lutein, L-glutathione reduced**, Ginkgo leaf extract ( Ginkgo biloba ) titrated in glycosides , Purslane aerial part powder (Portulaca oleracea) , Coenzyme Q10**, Zinc glycinate, S elenomethionine, Blueberry fruit extract ( Vaccinium myrtillus ) , Thiamine hydrochloride (vitamin B1), Riboflavin (vitamin B2), Nicotinamide (niacin - Vitamin B3), Calcium D-pantothenate (pantothenic acid - Vitamin B5), Hydrochloride of Pyridoxine (Vitamin B6), Calcium L-ascorbate (Vitamin C), Cholecalciferol (Vitamin D), D-alpha-tocopheryl acetate (Vitamin E), Rice extract, Pullulan vegetable capsule

    *Ingredients from Organic Farming

    **Ingredients from the fermentation process

    Nutritional information for a daily dose (2 capsules)

    Ingredients in mg for 2 capsules in % of AR*
    Grape seed extract 40mg -
    - of which OPC 28mg -
    Indian rose flower extract 50mg -
    - of which lutein 10mg -
    Bilberry extract (berry) 40mg -
    Gingko Biloba leaf extract 40mg -
    Purslane aerial part powder 40mg -
    Astaxanthin-rich oleoresin extracted from Haematococcus pluvialis seaweed
    80mg -
    - of which astaxanthin 4mg -
    CDP Choline 50mg -
    Reduced L-Glutathione 60mg -
    Coenzyme Q10 20mg -
    Zinc 11mg 92%
    Selenium 55mcg 79%
    Vitamin C 20mg 18%
    Vitamin E 20mg 160%
    Vitamin B1 1.3mg 100%
    Vitamin B2 0.84mg 60%
    Vitamin B3 9.6mg 60%
    Vitamin B5 7.2mg 120%
    Vitamin B6 1.7mg 100%
    Vitamin D3 5 mcg 33%
    * RI = Reference intakes for an adult male


    The particularity of ORetine comes from the diversity and the quantity of ingredients that we will seek from trusted producers. The grape seeds, for example, come from a winery in Costières de Nîmes, the lutein comes from Microphyt, a micro-algae grower near Montpellier, ...

    Once the ingredients are combined, ORetine is manufactured according to our guidelines by our manufacturing partner Phytocosma in the Gers, specialists in the plant and in the dry form of food supplements.

    HOW TO USE IT

    Dosage and taking instructions

    The dosage of ORetine is 2 capsules per day to be taken with a large glass of water.

    The consumption of ORetine can raise the levels of retinal pigments for several months.

    We therefore recommend an initial cure of 2 months of ORetine, renewable regularly. A personalized duration of the cure can be evaluated by a doctor, do not hesitate to consult your doctor or your ophthalmologist.

    The preservation of the eyes also goes through a healthy lifestyle, and some applicable tips to easily protect your eyes:

    • Always wear sunglasses in bright light

    • Add nuts and shelled fruits, egg, spinach, broccoli, oily fish to your diet to provide essential nutrients for vision.

    • Ensure a sufficient intake of Omega 3 (fatty fish) in the diet, i.e. twice 150g per week, or balance with food supplements based on Omega 3 (see our Omega complex -3 vegetarian)

      Contraindications, precautions for use and adverse effects

      • Do not use in case of known intolerance to any of the components.

      • Do not exceed the recommended daily dose.

      • Food supplements should be used as part of a healthy lifestyle and a varied and balanced diet.

      • Use in pregnant or breastfeeding women is not recommended.

      • Consult your doctor in case of simultaneous intake of anticoagulants or treatment of hypertension.

      • Use in people on antidepressant treatment is not recommended.

      • Keep out of reach of children.

      • Consumption reserved for adults

      • Prolonged use without medical advice is not recommended.

      • It is recommended to consult a doctor in the event of a specific pathology declared.

      Specific precautions linked to certain ingredients:

      Ginkgo biloba
      • People taking anticoagulant (blood thinner) medications should refrain from taking ginkgo products
      • People taking medication for high blood pressure should seek the advice of a physician before use
      • It is recommended to stop taking ginkgo three to four days before surgery
      • Headaches, digestive disorders ( diarrhea , bloating , gas, etc.), as well as allergic manifestations may occur after taking Ginkgo
      SCIENCE

      What are the health claims of the ORetine dietary supplement?

      Vitamin B1 in ORetine can claim to contribute:

      • normal energy metabolism
      • to the normal functioning of the heart
      • normal functioning of the nervous system and normal intellectual abilities

      ORetine by its vitamin B2 contribution can claim to contribute:

      • normal energy metabolism
      • normal functioning of the nervous system
      • maintenance of normal skin and mucous membranes
      • with normal vision
      • maintenance of normal red blood cells
      • normal iron metabolism
      • to the reduction of fatigue
      • protect cells against free radicals

      Vitamin B3 in ORetine contributes:

      • normal energy metabolism
      • normal functioning of the nervous system
      • maintenance of normal skin and mucous membranes
      • to normal physiological functions
      • to the reduction of fatigue

      Vitamin B5 in ORetine contributes:

      • normal energy metabolism
      • with normal intellectual capacity
      • to the synthesis of steroid hormones
      • to the synthesis of vitamin D
      • to the synthesis of certain neurotransmitters
      • to the reduction of fatigue

      ORetine by its vitamin D contribution can claim to contribute:

      • intestinal absorption and utilization of calcium and phosphorus
      • maintaining normal blood calcium levels
      • to the normal growth of children's bones
      • to maintain the normal state of the bones
      • maintaining the normal state of the muscles
      • to maintain the normal state of the teeth
      • to maintain the normal state of the immune system
      • to cell division

      ORetine by its vitamin E contribution can claim to contribute:

      • the protection of cells against free radicals (antioxidant effect)

      ORetine by its zinc contribution can claim to contribute:

      • to normal DNA synthesis
      • normal acid-base metabolism
      • normal food metabolism
      • normal carbohydrate (sugar) metabolism
      • normal fatty acid metabolism
      • normal vitamin A metabolism
      • to normal intellectual functions
      • to normal fertility and reproduction
      • to protein synthesis
      • maintaining bones
      • maintenance of hair, nails and skin
      • maintaining normal testosterone levels in the blood
      • with normal vision
      • the normal functioning of the immune system
      • to cell division
      • protect cells against free radicals

      What the science says

      The AREDS and AREDS 2 studies that were used to develop our formula ← Click to see the references

      (1) Age-Related Eye Disease Studies (AREDS/AREDS2)

      (2) AREDS2 Research Group, Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012 Nov;119(11):2282-9. doi: 10.1016/j.ophtha.2012.05.027.

      (3) Sangiovanni JP, Agron E, Meleth AD, Reed GF, Sperduto RD, Clemons TE, Chew EY; Age-Related Eye Disease Study Research Group. {omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study. Am J Clin Nutr. 2009 Dec;90(6):1601-7. doi: 10.3945/ajcn.2009.27594.

      (4) Kowluru RA, Kanwar M, Chan PS, Zhang JP. Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Arch Ophthalmol. 2008 Sep;126(9):1266-72. doi: 10.1001/archopht.126.9.1266.

      Proanthocyanidins extracted from grape seeds protect the lens from oxidative stress ← Click to see references

      (5) Jia Z, Song Z, Zhao Y, Wang X, Liu P. Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-кB and MAPK protein expression. MolVis. 2011 Jan 20;17:210-7.

      (6) Sun Y, Xiu C, Liu W, Tao Y, Wang J, Qu YI. Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway. Exp Ther Med. 2016 Apr;11(4):1253-1258. doi: 10.3892/etm.2016.3033.

      Coenzyme Q10, which decreases with age, exerts a protective effect on the retina ← Click to see references

      (7) Qu J, Kaufman Y, Washington I. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1814-8. doi: 10.1167/iovs.08-2656.

      (8) Sangsefidi ZS, Yaghoubi F, Hajiahmadi S, Hosseinzadeh M. The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Food Sci Nutr. 2020 Mar 19;8(4):1766-1776. doi: 10.1002/fsn3.1492.

      (9) Manzar H, Abdulhussein D, Yap TE, Cordeiro MF. Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain. Int J Mol Sci. 2020 Dec 6;21(23):9299. doi: 10.3390/ijms21239299.

      Bilberry (thanks to these polyphenols and antocyanins) has night vision protection and improvement effects ← Click to see references

      (10) Chu WK, Cheung SCM, Lau RAW, Benzie IFF. Bilberry (Vaccinium myrtillus L.). In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.

      (11) Kalt W, McDonald JE, Fillmore SA, Tremblay F. Blueberry effects on dark vision and recovery after photobleaching: placebo-controlled crossover studies. J Agric Food Chem. 2014 Nov 19;62(46):11180-9. doi: 10.1021/jf503689c.

      (12) Liu Y, Zhang D, Hu J, Liu G, Chen J, Sun L, Jiang Z, Zhang X, Chen Q, Ji B. Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols. J Agric Food Chem. 2015 Oct 28;63(42):9295-305. doi: 10.1021/acs.jafc.5b04341.

      CDP-Choline (citicoline) exerts neuroprotective effects ← Click to view references

      (13) Parisi V, Coppola G, Ziccardi L, Gallinaro G, Falsini B. Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy. Eur J Neurol. 2008 May;15(5):465-74. doi: 10.1111/j.1468-1331.2008.02099.x.

      (14) Arenth PM, Russell KC, Ricker JH, Zafonte RD. CDP-choline as a biological supplement during neurorecovery: a focused review. PM R. 2011 Jun;3(6 Suppl 1):S123-31. doi: 10.1016/j.pmrj.2011.03.012.

      (15) Park CH, Kim YS, Noh HS, Cheon EW, Yang YA, Yoo JM, Choi WS, Cho GJ. Neuroprotective effect of citicoline against KA-induced neurotoxicity in the rat retina. Exp Eye Res. 2005 Sep;81(3):350-8. doi: 10.1016/j.exer.2005.02.007.

      Astaxanthin, its antioxidant and anti-inflammatory effects on the retina and the body ← Click to see references

      (16) Otsuka T, Shimazawa M, Nakanishi T, Ohno Y, Inoue Y, Tsuruma K, Ishibashi T, Hara H. Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage. J Pharmacol Sci. 2013;123(3):209-18. doi: 10.1254/jphs.13066fp.

      (17) Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011 Dec;16(4):355-64.

      (18) Lin CW, Yang CM, Yang CH. Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model. Mar Drugs. 2020 Jul 25;18(8):387. doi: 10.3390/md18080387.

      Lutein (a carotenoid) is an essential component of the eye and helps protect against AMD ← Click to view references

      (19) Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013 May 15;309(19):2005-15. doi: 10.1001/jama.2013.4997.

      (20) Murray IJ, Makridaki M, van der Veen RL, Carden D, Parry NR, Berendschot TT. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Invest Ophthalmol Vis Sci. 2013 Mar 11;54(3):1781-8. doi: 10.1167/iovs.12-10715.

      (21) Li LH, Lee JC, Leung HH, Lam WC, Fu Z, Lo ACY. Lutein Supplementation for Eye Diseases. Nutrients. 2020 Jun 9;12(6):1721. doi: 10.3390/nu12061721.

      Purslane is an anti-inflammatory and anti-oxidant ← Click to see references

      (22) Rahimi VB, Ajam F, Rakhshandeh H, Askari VR. A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti-Oxidant, Immuno-Modulatory and Antitumor Activities. J Pharmacopuncture. 2019 Mar;22(1):7-15. doi: 10.3831/KPI.2019.22.001.

      INSERM press release: What should you eat to prevent the onset or slow the progression of AMD? ← Click to see references

      (23) Consuming a diet rich in carotenoids lowers the risk of developing AMD

      The information in this sheet takes into account the framework of authorized health claims in accordance with European legislation on food supplements (EC No. 1924/2006).

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