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Ilustration: Les pigments caroténoïdes : un allié pour la santé oculaire

What is the role of carotenoid pigments in the proper functioning of the eye?

D
Dr. Arnaud BERNARD
8 min

Carotenoid pigments are natural compounds that give fruits and vegetables their characteristic color. Some of these pigments have shown beneficial effects on eye health. Indeed, scientific studies have suggested that carotenoids may help prevent or delay certain eye diseases, including age-related macular degeneration (AMD) and cataracts. In this article, we will explore the benefits of carotenoid pigments for vision and the prevention of these diseases, as well as the dietary sources that provide them.

What are carotenoid pigments?

Carotenoid pigments are organic compounds found in plants, algae, and photosynthetic bacteria. More than 600 carotenoids exist, but only about twenty have been identified in human tissues, primarily in the retina and lens of the eye. The two main carotenoids present in the eye are lutein and zeaxanthin. They are mainly absorbed from food and cannot be synthesized by the human body. Therefore, it is essential to obtain them through an appropriate dietary intake.

What are the effects of carotenoid pigments on vision?

Carotenoid pigments have been linked to a reduced risk of developing certain eye diseases. Age-related macular degeneration (AMD), a degenerative disease of the retina, is the leading cause of blindness in people over 50. Carotenoids have been studied for their role in preventing or delaying this disease. In fact, a study published in the British Journal of Ophthalmology showed that consuming foods rich in lutein and zeaxanthin was associated with a 43% reduction in the risk of developing AMD.

Furthermore, carotenoids have also been studied for their role in preventing cataracts, a clouding of the eye's lens that can affect vision. A 2016 study published in the journal Nutrients showed that carotenoid consumption, particularly lutein and zeaxanthin, was associated with a decreased prevalence of cataracts in adults.

The interest in carotenoids for eye health and the prevention of age-related eye diseases has led to the implementation of large-scale clinical studies such as the AREDS (Age-Related Eye Disease Study) and AREDS2 studies, whose objectives were to evaluate the ability of a mixture of carotenoids, antioxidants and vitamins to protect the eye.

Does zinc improve eyesight?

Zinc is an essential trace element for eye health and the prevention of certain eye diseases. Indeed, zinc is present in large quantities in the retina and plays an important role in the production of melanin, a pigment that protects the retina from light damage. It is also involved in the production of hyaluronic acid, a substance that maintains the structure of eye tissues.

Studies have shown that zinc can help slow the progression of age-related macular degeneration (AMD). Results from the AREDS study showed that zinc supplementation, in combination with other antioxidants such as vitamin C, vitamin E, and carotenoid pigments, reduces the risk of AMD progression by 25% in people with advanced AMD.

Zinc is also important for maintaining normal vision in low light conditions, as it is needed for the production of rhodopsin, a light-sensitive pigment found in the rods of the retina.

It is recommended that adults consume approximately 8 to 11 mg of zinc per day, depending on age and sex. Foods rich in zinc include seafood, red meat, nuts, and legumes.

Caution: It is important not to take excessive amounts of zinc supplements, as overconsumption is harmful. Therefore, avoid taking multiple zinc supplements simultaneously without consulting a healthcare professional.

What are the effects of lutein?

Lutein is a carotenoid pigment that can help prevent eye diseases and maintain visual health. Like zeaxanthin, lutein is present in high quantities in the macula, the central part of the retina responsible for sharp vision.

One of the main benefits of lutein for the eyes is its role in filtering blue light. Blue light, emitted by computer screens, cell phones, and other sources, can cause long-term damage to the retina. However, lutein helps block blue light and prevent the resulting damage.

Furthermore, studies have shown that lutein can reduce the risk of developing age-related macular degeneration (AMD) and other age-related eye diseases. Individuals consuming high levels of lutein and zeaxanthin had a significantly lower risk of developing AMD.

Lutein can also help reduce inflammation in the eyes, which may help prevent eye diseases. Foods rich in lutein include spinach, kale, bell peppers, broccoli, squash, and egg yolks.

The recommended amount of lutein depends on several factors, including age, sex, and overall health. Generally, a daily intake of 6 to 20 mg of lutein is recommended to maintain good eye health.

In short, lutein is a carotenoid pigment that plays an important role in eye health. It helps filter blue light, reduces inflammation in the eyes, and may help prevent age-related eye diseases. Foods rich in lutein can be an excellent source of this important nutrient for maintaining good eye health.

What are the effects of asthaxanthin?

Astaxanthin is a carotenoid pigment found in algae, yeast, seafood, fish, and some microalgae. It is known for its antioxidant and anti-inflammatory properties, and studies have shown that it may also have beneficial effects on eye health.

Indeed, astaxanthin is able to cross the blood-retinal barrier and concentrate in the retina, where it can protect cells against oxidative and inflammatory damage.

It has been highlighted in patients with age-related macular degeneration (AMD) that patients who received astaxanthin exhibit improved contrast sensitivity and decreased retinal thickness, suggesting a reduction in inflammation.

Other studies have also suggested that astaxanthin may help prevent cataracts, a clouding of the lens that can cause blurred vision. One animal study showed that astaxanthin could reduce the buildup of proteins in the lens, a key factor in the development of cataracts.

It has also been suggested that astaxanthin can help reduce eye strain in people who regularly use a computer or smartphone. Researchers have attributed this to astaxanthin's ability to reduce inflammation and improve blood flow to the eyes. This may help prevent eye fatigue, dry eyes, and other symptoms associated with prolonged screen use.

It is important to note that research on astaxanthin is still relatively new and limited. However, the initial studies are very promising, and astaxanthin is considered a beneficial nutrient for eye health.

Conclusion

Carotenoid pigments like lutein and astaxanthin may play an important role in eye health by protecting the eyes from free radical damage and reducing inflammation. While research on these nutrients is still ongoing, current evidence suggests that their consumption may help prevent or slow the development of some common eye diseases, such as age-related macular degeneration (AMD) and cataracts. Carotenoid pigments are powerful antioxidants that protect the eye and the body from the damage caused by oxidative stress.

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In addition, to enhance the effectiveness of the formula, we have added a concentrated extract of Haematococcus pluvialis seaweed, which provides astaxanthin , the most powerful natural antioxidant .

You can find all our vision support supplements in our catalogue of food supplements .

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Frequently Asked Questions about Carotenoids and Vision

What are the effects of lutein?

Lutein is a carotenoid pigment that protects the retina against oxidative damage and reduces the risk of developing age-related eye diseases.

Does zinc improve eyesight?

Zinc is important for eye health, but it has not been shown to directly improve vision. It is important to consult a healthcare professional before taking zinc supplements, as high doses may have adverse effects.

What is the best vitamin for the eyes?

Vitamins C and E, as well as carotenoid pigments such as lutein, astaxanthin, and zeaxanthin, are important for eye health.

What foods are rich in lutein?

Foods rich in lutein include leafy green vegetables, such as spinach, kale, and turnip greens, as well as egg yolks.

How much lutein per day?

There is no specific daily dose recommendation for lutein, but an intake of about 10 milligrams per day is considered beneficial for eye health.

What are the benefits of lutein?

Lutein protects the retina against oxidative damage and reduces the risk of developing age-related eye diseases.

What are the benefits of astaxanthin?

Astaxanthin is a more powerful antioxidant than lutein and zeaxanthin, and it can help protect the retina as well as the rest of the body against oxidative stress.

Sources

ANSES opinion

ANSES opinion on lens protection

Reducing the risk of AMD

Age-Related Eye Disease Study Research Group. “A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8.” Archives of Ophthalmology 119, no. 10 (October 1, 2001): 1417–36. https://doi.org/10.1001/archopht.119.10.1417.

Roubeix, Christophe, José-Alain Sahel, Xavier Guillonneau, Cécile Delarasse, and Florian Sennlaub. “On the inflammatory origins of AMD”. medicine/science 36, no. 10 (October 2020): 886–92. https://doi.org/10.1051/medsci/2020159.

AMELI: Consultation and treatment of dry eye

AMELI: Symptoms of dry eye

VIDAL: dry eyes

Ophthalmology Notebooks: Special Issue on Dry Eye

Mares J. Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annu Rev Nutr. 2016 Jul 17;36:571-602. doi: 10.1146/annurev-nutr-071715-051110. PMID: 27431371

Wilson LM, Thamarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. Adv Nutr. 2021 Dec 1;12(6):2244-2254. doi:10.1093/advances/nmab071.

Inserm: AMD

Ameli: AMD

SNOF: AMD

Inserm: Risk factors for AMD

Consuming a diet rich in carotenoids reduces the risk of developing age-related macular degeneration (AMD).

AREDS2 Research Group, Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012 Nov;119(11):2282-9. doi: 10.1016/j.ophtha.2012.05.027.

C. Creuzot-Garcher. Dry eye related to systemic medications. French Journal of Ophthalmology. 2008

Moen BE, Norbäck D, Wieslander G, Bakke JV, Magerøy N, Granslo JT, Irgens A, Bråtveit M, Hollund BE, Aasen T. Can air pollution affect tear film stability? A cross-sectional study in the aftermath of an explosion accident. BMC Public Health. 2011 Apr 14;11:235. doi:10.1186/1471-2458-11-235.

Rosenfield M. Computer vision syndrome: a review of ocular causes and potential treatments. Ophthalmic Physiol Opt. 2011 Sep;31(5):502-15. doi: 10.1111/j.1475-1313.2011.00834.x. Epub 2011 Apr 12.

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FAQ

Pour intégrer les caroténoïdes dans votre alimentation, privilégiez la consommation de fruits et légumes colorés, notamment les épinards, le chou frisé, les carottes et les poivrons. Vous pouvez également envisager des smoothies ou des salades riches en légumes, et inclure des jaunes d'œufs pour augmenter votre apport en lutéine et zéaxanthine.

Bien que les caroténoïdes soient généralement considérés comme sûrs, une consommation excessive de suppléments peut entraîner une coloration jaunâtre de la peau, connue sous le nom de carotenodermie. Il est important de consulter un professionnel de la santé avant de commencer tout supplément pour éviter les interactions ou effets indésirables.

Oui, les caroténoïdes peuvent également être bénéfiques pour les enfants, car ils soutiennent le développement sain des yeux et renforcent le système immunitaire. Il est conseillé de leur offrir une alimentation équilibrée, riche en fruits et légumes contenant des caroténoïdes pour favoriser leur santé oculaire dès le plus jeune âge.

Il est préférable de consommer des aliments riches en caroténoïdes au cours des repas, car leur absorption est améliorée lorsqu'ils sont associés à des graisses saines, comme celles contenues dans l'avocat ou les noix. Inclure ces aliments dans vos plats principaux ou vos collations peut maximiser leurs bienfaits.

Oui, certains caroténoïdes peuvent interagir avec des médicaments, notamment ceux affectant l'absorption des graisses ou des anticoagulants. Il est essentiel de discuter avec votre médecin ou un pharmacien avant d'ajouter des suppléments de caroténoïdes à votre régime, surtout si vous prenez d'autres médicaments.

Les caroténoïdes sont des précurseurs de la vitamine A, ce qui signifie qu'ils peuvent être convertis en vitamine A par l'organisme. Toutefois, tous les caroténoïdes ne se transforment pas en vitamine A, et il est important de consommer des sources variées pour bénéficier de leurs différents effets sur la santé.