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Illustration: le méthyl sulfonyle méthane dans les compléments alimentaires

Ingredient information: Methylsulfonylmethane in food supplements

Written by the Phytocea team Reviewed by Phytocea Scientific Advisory Board Editorial credit: Dr. Arnaud BERNARD
3 min
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What is methylsulfonylmethane, or MSM?

Methylsulfonylmethane (MSM) is a molecule belonging to the sulfone family (sulfones are sulfur-containing organic compounds with a sulfonyl group). It is also known as MSM or dimethylsulfone. It is present in the body and is found in food.

MSM is used in dietary supplements intended for joints or hair/skin/nails.

What are the benefits of MSM?

MSM is a natural source of organic sulfur, which is found in large quantities in the collagen present in the skin and joints. It is an essential compound for the synthesis of cartilage components.

It is used in food supplements for both humans and animals (horses, dogs), particularly for its anti-inflammatory effects.

Thanks to the sulfur it contains, MSM is believed to have benefits in preserving the immune system and in renewing connective tissues.

Methylsulfonylmethane (MSM) for osteoarthritis

MSM is widely used in food supplements for the management of osteoarthritis, because the sulfur it contains is highly bioavailable and participates in the synthesis of cartilage constituents.

Methylsulfonylmethane (MSM) for hair, nails and hair

MSM has been shown to promote accelerated hair growth and improve skin quality. The sulfur provided by MSM contributes to keratin synthesis.

Where can I find MSM?

Methylsulfonylmethane is present in food, particularly in:

  • Algae

  • Seafood

  • Cow's milk

  • Fruits

  • Vegetables

  • Eggs

However, it is altered by cooking.

They are also found as an ingredient in some dietary supplements.

What are the health claims of the MSM?

Methylsulfonylmethane does not have any health claims validated by the EFSA.

What are the precautions for use and the side effects of MSM?

Precautions for use

As with most dietary supplements, methylsulfonylmethane is not recommended for pregnant or breastfeeding women, who should always seek medical advice before taking any supplements.

It is recommended not to consume MSM in case of kidney problems or during chemotherapy treatments.

Side effects

MSM can sometimes cause:

  • Nausea

  • Mild intestinal problems (diarrhea, constipation)

  • Headaches

Methylsulfonylmethane (MSM) in Phytocea food supplements

At Phytocea , we have incorporated MSM into the formula of ReGlow, our special food supplement for nails, skin and hair.

ReGlow is a plant-based and vitamin-based food supplement designed to promote clear skin and maintain the quality of nails and hair, containing a mixture of plants, nutrients, and substances with nutritional or physiological purposes.

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What the research says

Guaitolini E, Cavezzi A, Cocchi S, Colucci R, Urso SU, Quinzi V. Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. J Clin Aesthet Dermatol. 2019 Apr;12(4):40-45.

Muizzuddin N, Benjamin R. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin aging. Int J Vitam Nutr Res. 2022 Jul;92(3-4):182-191. doi:10.1024/0300-9831/a000643.

Shanmugam S, Baskaran R, Sriraman SN, Yong CS, Choi HG, Woo JS, , Yoo BK. The Effect of Methylsulfonylmethane on Hair Growth Promotion of Magnesium Ascorbyl Phosphate for the Treatment of Alopecia. Biomolecules & Therapeutics 2009;17:241-48. doi: 10.4062/biomolther.2009.17.3.241

S p N, Kang DY, Kim HD, Rugamba A, Jo ES, Park JC, Bae SW, Lee JM, Jang KJ. Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-κB Signaling in CCD-986Sk Skin Fibroblasts. Life (Basel). 2021 May 10;11(5):427. doi:10.3390/life11050427 .

Berardesca E, Cameli N, Cavallotti C, Levy JL, Piérard GE, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7(1):8-14. doi: 10.1111/j.1473-2165.2008.00355.x.

Usha PR, Naidu MU. Randomized, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. doi:10.2165/00044011-200424060-00005.

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. doi: 10.1016/j.joca.2005.10.003.

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FAQ

Oui, le MSM peut être associé à d'autres compléments alimentaires, notamment ceux contenant de la glucosamine ou du collagène, pour un effet synergique sur la santé des articulations et de la peau. Cependant, il est conseillé de consulter un professionnel de santé avant de combiner plusieurs produits.

Pour choisir un complément alimentaire contenant du MSM, vérifiez la concentration de MSM par dose, la présence d'autres ingrédients bénéfiques, ainsi que la réputation de la marque. Recherchez également des produits qui respectent des normes de qualité et de sécurité.

La dose recommandée de MSM varie généralement entre 1 et 3 grammes par jour, mais il est essentiel de suivre les recommandations du fabricant ou de consulter un professionnel de santé pour déterminer la dose appropriée selon vos besoins spécifiques.

Le MSM n'est pas recommandé pour les enfants sans supervision médicale. Les effets du MSM sur les enfants n'ont pas été suffisamment étudiés, donc il est préférable de consulter un pédiatre avant d'envisager son utilisation.

Les signes d'une réaction allergique au MSM peuvent inclure des démangeaisons, des éruptions cutanées, ou un gonflement. Si vous ressentez des symptômes inhabituels après avoir pris du MSM, il est important de consulter un professionnel de santé rapidement.

Le MSM peut interagir avec certains médicaments, notamment ceux qui affectent la coagulation sanguine ou les traitements pour le diabète. Il est donc crucial d'en parler à votre médecin si vous prenez des médicaments sur ordonnance.

Le MSM est un composé organique naturellement présent dans certaines plantes, légumes, et fruits de mer. La plupart des compléments de MSM disponibles sur le marché sont d'origine synthétique ou dérivés de sources végétales.